Disease Analysis toolkit for gene set; Computation of similarities between DO terms and disease similarity between gene products; Module detection among the gene set and multilayer annotation for each module This package implements multiple similarity measures for DO terms and gene products. It is aiming at disease analyis for gene sets. Modules of a gene set could be detected and further multilayer annoated on DO, GO and KEGG. We also provides users to conduct DO enrichment analysis and basic information fetching for DO.DOSim: An R package for similarity between diseases based on Disease Ontology(http://www.biomedcentral.com/1471-2105/12/266) Software Depends: R (>= 2.10), GOSim, dynamicTreeCut, moduleColor, RBGL, graph, Rgraphviz Jiang Li <riverlee2008@gmail.com> Jiang Li <riverlee2008@gmail.com> GPL (>= 2) 2012-02-13 application/tgz http://CRAN.R-project.org/package=DOSim